Most Tissues

Glutamate Glutamine ATP + NH3 synthetase ADP + P;

Glutamine

H20 Glutaminase

Urea <—NH3

Glutamate dehydrogenase

a-ketoglutarate Glutamate

Alanine “l@nine pyruvate amino- transferase |

Glucose

Glucose Alanine Cycle

Glucose

Alanine Alanine amino- Pyruvate

a-ketoglutarate Glutamate Glutamate dehydrogenase NH3

Amino acids

Liver

Muscle